DNP 810 Why is it important to have a comprehensive health and physical assessment that includes information on environment and genomic influences?

DNP 810 Why is it important to have a comprehensive health and physical assessment that includes information on environment and genomic influences?

Sample Answer for DNP 810 Why is it important to have a comprehensive health and physical assessment that includes information on environment and genomic influences? Included After Question

Why is it important to have a comprehensive health and physical assessment that includes information on environment and genomic influences? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.

A Sample Answer For the Assignment: DNP 810 Why is it important to have a comprehensive health and physical assessment that includes information on environment and genomic influences?

Title: DNP 810 Why is it important to have a comprehensive health and physical assessment that includes information on environment and genomic influences?

The etiologic paradigm of complex human disorders such as autism is that genetic and environmental risk factors are independent and additive, but the interactive effects at the epigenetic interface are largely ignored. Genomic technologies have radically changed perspective on the human genome and how the epigenetic interface may impact complex human disorders. Here, I review recent genomic, environmental and epigenetic findings that suggest a new paradigm of “integrative genomics” in which genetic variation in genomic size may be impacted by dietary and environmental factors that influence the genomic saturation of DNA methylation. Human genomes are highly repetitive, but the interface of large-scale genomic differences with environmental factors that alter the DNA methylome such as dietary folate is under-explored.

In addition to obvious direct effects of some environmental toxins on the genome by causing chromosomal breaks, non-mutagenic toxin exposures correlate with DNA hypomethylation that can lead to rearrangements between repeats or increased retrotransposition. Since human neurodevelopment appears to be particularly sensitive to alterations in epigenetic pathways, a further focus will be on how developing neurons may be particularly impacted by even subtle alterations to DNA methylation and proposing new directions towards understanding the quixotic etiology of autism by integrative genomic approaches.

DNP 810 Why is it important to have a comprehensive health and physical assessment that includes information on environment and genomic influences
DNP 810 Why is it important to have a comprehensive health and physical assessment that includes information on environment and genomic influences

Environmental Toxins Negatively Impact Global DNA Methylation

The epigenetic modification of DNA methylation acts at the interface of genetic and environmental factors. As part of the emerging field of “environmental epigenetics,” a variety of environmental toxins with known adverse impacts on human health or neurodevelopment have been investigated for their potential effects on DNA methylation and other epigenetic effects (reviewed in ref. ). Arsenic, cadmium, benzene and air pollution are exposures associated with reduction of DNA methylation levels at LINE1 and/or Alu repeats in human tissues.– In mouse models of human exposures, methylmercury resulted in hypermethylation of brain derived neurotropic factor (Bdnf) in hippocampus and diethylstilbestrol exposure reduced global methylation in the uterus. In a human Greenlandic Inuit population with high persistent organic pollutant (POP) levels, reduced global DNA methylation (LINE1) was observed with increased POP levels. Furthermore, prenatal exposure of a rat model with organochloride pesticides, methylmercury, POPs or a mixture of all three chemical classes showed that POPs in the mixture correlated with reduced DNA methylation levels in liver.

Within the class of POPs, polychlorinated biphenyls (PCBs) are a widely distributed class of environmental pollutants previously used in industrial products until adverse health effects were recognized in the 1970s resulting in discontinued use. The developmental neurotoxicity of PCBs became devastatingly apparent after the large-scale consumption of PCB-contaminated rice oil that occurred in 1968 in Japan and in 1979 in Taiwan., PCBs are known to disrupt neurotransmitter systems, endocrine systems and intracellular signaling pathways., While PCB levels are gradually declining in the environment following the discontinued use, a related class of POPs, the polybrominated diphenyl ethers (PBDEs), are currently used as commercial flame-retardants and are a growing concern for human exposures. Our recent analyses of perinatal PBDE exposure in a genetic mouse model susceptible to social behavioral deficits showed global hypomethylation in brain associated with adverse social and cognitive behavioral outcomes (Woods et al., in preparation).

The major future challenge that will be explored in this review is understanding how DNA methylation of human repetitive elements interacts with environmental risk and protective factors in the etiology of a complex genetic disorder such as autism.

Click here to ORDER an A++ paper from our Verified MASTERS and DOCTORATE WRITERS: DNP 810 Why is it important to have a comprehensive health and physical assessment that includes information on environment and genomic influences?

Lopes Write Policy

For assignments that need to be submitted to Lopes Write, please be sure you have received your report and Similarity Index (SI) percentage BEFORE you do a “final submit” to me.

Once you have received your report, please review it. This report will show you grammatical, punctuation, and spelling errors that can easily be fixed. Take the extra few minutes to review instead of getting counted off for these mistakes.

Review your similarities. Did you forget to cite something? Did you not paraphrase well enough? Is your paper made up of someone else’s thoughts more than your own?

Visit the Writing Center in the Student Success Center, under the Resources tab in LoudCloud for tips on improving your paper and SI score.

Late Policy

The university’s policy on late assignments is 10% penalty PER DAY LATE. This also applies to late DQ replies.

Please communicate with me if you anticipate having to submit an assignment late. I am happy to be flexible, with advance notice. We may be able to work out an extension based on extenuating circumstances.

If you do not communicate with me before submitting an assignment late, the GCU late policy will be in effect.

I do not accept assignments that are two or more weeks late unless we have worked out an extension.

As per policy, no assignments are accepted after the last day of class. Any assignment submitted after midnight on the last day of class will not be accepted for grading.

Communication

Communication is so very important. There are multiple ways to communicate with me:

Questions to Instructor Forum: This is a great place to ask course content or assignment questions. If you have a question, there is a good chance one of your peers does as well. This is a public forum for the class.

Individual Forum: This is a private forum to ask me questions or send me messages. This will be checked at least once every 24 hours.

Important information for writing discussion questions and participation

Welcome to class

Hello class and welcome to the class and I will be your instructor for this course. This is a -week course and requires a lot of time commitment, organization, and a high level of dedication. Please use the class syllabus to guide you through all the assignments required for the course. I have also attached the classroom policies to this announcement to know your expectations for this course. Please review this document carefully and ask me any questions if you do. You could email me at any time or send me a message via the “message” icon in halo if you need to contact me. I check my email regularly, so you should get a response within 24 hours. If you have not heard from me within 24 hours and need to contact me urgently, please send a follow up text to

I strongly encourage that you do not wait until the very last minute to complete your assignments. Your assignments in weeks 4 and 5 require early planning as you would need to present a teaching plan and interview a community health provider. I advise you look at the requirements for these assignments at the beginning of the course and plan accordingly. I have posted the YouTube link that explains all the class assignments in detail. It is required that you watch this 32-minute video as the assignments from week 3 through 5 require that you follow the instructions to the letter to succeed. Failure to complete these assignments according to instructions might lead to a zero. After watching the video, please schedule a one-on-one with me to discuss your topic for your project by the second week of class. Use this link to schedule a 15-minute session. Please, call me at the time of your appointment on my number. Please note that I will NOT call you.

Please, be advised I do NOT accept any assignments by email. If you are having technical issues with uploading an assignment, contact the technical department and inform me of the issue. If you have any issues that would prevent you from getting your assignments to me by the deadline, please inform me to request a possible extension. Note that working fulltime or overtime is no excuse for late assignments. There is a 5%-point deduction for every day your assignment is late. This only applies to approved extensions. Late assignments will not be accepted.

If you think you would be needing accommodations due to any reasons, please contact the appropriate department to request accommodations.

Plagiarism is highly prohibited. Please ensure you are citing your sources correctly using APA 7th edition. All assignments including discussion posts should be formatted in APA with the appropriate spacing, font, margin, and indents. Any papers not well formatted would be returned back to you, hence, I advise you review APA formatting style. I have attached a sample paper in APA format and will also post sample discussion responses in subsequent announcements.

Your initial discussion post should be a minimum of 200 words and response posts should be a minimum of 150 words. Be advised that I grade based on quality and not necessarily the number of words you post. A minimum of TWO references should be used for your initial post. For your response post, you do not need references as personal experiences would count as response posts. If you however cite anything from the literature for your response post, it is required that you cite your reference. You should include a minimum of THREE references for papers in this course. Please note that references should be no more than 5 years old except recommended as a resource for the class. Furthermore, for each discussion board question, you need ONE initial substantive response and TWO substantive responses to either your classmates or your instructor for a total of THREE responses. There are TWO discussion questions each week, hence, you need a total minimum of SIX discussion posts for each week. I usually post a discussion question each week. You could also respond to these as it would count towards your required SIX discussion posts for the week.

I understand this is a lot of information to cover in 5 weeks, however, the Bible says in Philippians 4:13 that we can do all things through Christ that strengthens us. Even in times like this, we are encouraged by God’s word that we have that ability in us to succeed with His strength. I pray that each and every one of you receives strength for this course and life generally as we navigate through this pandemic that is shaking our world today. Relax and enjoy the course!

Hi Class,

Please read through the following information on writing a Discussion question response and participation posts.

Contact me if you have any questions.

Important information on Writing a Discussion Question

  • Your response needs to be a minimum of 150 words (not including your list of references)
  • There needs to be at least TWO references with ONE being a peer reviewed professional journal article.
  • Include in-text citations in your response
  • Do not include quotes—instead summarize and paraphrase the information
  • Follow APA-7th edition
  • Points will be deducted if the above is not followed

Participation –replies to your classmates or instructor

  • A minimum of 6 responses per week, on at least 3 days of the week.
  • Each response needs at least ONE reference with citations—best if it is a peer reviewed journal article
  • Each response needs to be at least 75 words in length (does not include your list of references)
  • Responses need to be substantive by bringing information to the discussion or further enhance the discussion. Responses of “I agree” or “great post” does not count for the word count.
  • Follow APA 7th edition
  • Points will be deducted if the above is not followed
  • Remember to use and follow APA-7th edition for all weekly assignments, discussion questions, and participation points.
  • Here are some helpful links
  • Student paper example
  • Citing Sources
  • The Writing Center is a great resource