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 NURS 6501 Discussion Alterations in Cellular Processes

 NURS 6501 Discussion Alterations in Cellular Processes
Week 1

I evaluated a situation in which a pediatric patient was diagnosed with cystic fibrosis. The 6-month-old was noted as having belly edema following feedings, slow weight gain, and salty skin. Additionally, the scenario included information on a sibling’s history of respiratory difficulties and hospitalizations.

Genetics

Cystic fibrosis is genuinely a hereditary disease that manifests only when both parents are carriers. Cystic fibrosis is an autosomal recessive disease that requires each parent to inherit two mutant transmembrane conductance regulator or (CFTR) delta F508 genes. Miller et al. This expression indicates that both parents are heterozygous for cystic fibrosis and that their offspring have a 25% probability of acquiring the condition. Consanguinity or offspring from related individuals is frequently a role in recessive illnesses. 2020 (Huether & McCance) Interestingly, this infant’s parents may be related or may have shared a parent who was a carrier.

Symptoms

The patient appears with stomach pain, distention, and a history of inadequate weight gain. The infant’s digestive tract and pancreatic ducts were most likely clogged with thick mucus. According to Afloarei (2020), mucus buildup in the pancreas limits the entry of digestive enzymes into the digestive tract and inhibits fat digestion. This would account for the patient’s lack of weight gain. According to Yap et al. (2014), 20% of individuals with cystic fibrosis present with a newborn intestinal blockage caused by meconium bowel obstructions or volvulus-induced ischemia. This meconium may have moved slowly through the infant’s bowels until it encountered a twist or loop. A meconium bowel blockage is quite harmful. According to Afloarei (2020), this sort of bowel obstruction may result in intestinal perforation and septic shock. I would recommend immediate consultation with a surgeon or other emergency care. Cellular Processes Modifications Discussion of NURS 6501

The physiologic response

The response noted by the mother was directly related to the stimulus of feedings. The infant’s reaction to ingesting the food caused the cells within the pancreas to produce digestive enzymes. The enzymes are blocked from entering the infant’s digestive tract, and the enzymes react with the cells of the pancreas, causing inflammation and pain. (Afloarei, 2020) Additionally, Afloarei (2020) relates the lack of enzymes entering the digestive tract leads to absorption issues and poor weight gain. This poor child is practically starving and experiencing excruciating pain when it attempts to remedy its hunger.

The cells

The cells involved with this disease are present primarily on the skin, digestive tract, and respiratory tract. This chloride and bicarbonate channel within these epithelial cells’ cell membranes is not functional (Miller et al., 2019). The cells are then incapable of moving chloride outside the cell membrane. Afloarei (2020) noted that the chloride’s transport, outside the cell, usually is responsible for thinning secretions within these bodily systems, and its absence leads to thick tenacious secretions. The secretions can then lead to obstructions that end up damaging the organ systems over time.

 NURS 6501 Discussion Alterations in Cellular Processes

NURS 6501 Discussion Alterations in Cellular Processes

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Other chacteristics

Both parents of the infant definitely would benefit from education on cystic fibrosis. I would initiate education on the basics of the

disease and refer her to local support groups. The mother inquired about potentially having additional children. I would use the illustration of the punnet’s square to illustrate the potential for disease transmission. Huether and McCance. (2020) stated average, 25% of the carriers’ offspring will be affected, 50% will be carriers, and 25% will be unaffected. I would do my best to explain the future medical experiences that are yet to come and stress the potential difficulties. This topic would be a difficult subject to approach, as personal opinions would be hard to exclude. Alterations in Cellular Processes NURS 6501 Discussion

References

Afloarei, D. (2020). High yield cystic fibrosis (S. Gillespie, Ed.). Osmosis.org. https://www.osmosis.org/learn/High_Yield:_Cystic_fibrosis

Huether, S., & McCance, K. (2020). Pathophysiology the biologic basis for diseasein adults and children (8th ed.). Elsevier Health Sciences (US).

Miller, A. C., Comellas, A. P., Hornick, D. B., Stoltz, D. A., Cavanaugh, J. E., Gerke, A. K., Welsh, M. J., Zabner, J., & Polgreen, P. M. (2019). Cystic fibrosis carriers are at increased risk for a wide range of cystic fibrosis-related conditions. Proceedings of the National Academy of Sciences, 117(3), 1621–1627. https://doi.org/10.1073/pnas.1914912117

Sue Huether, Kathryn McCance. (2020). Pathophysiology the biologic basis for diseasein adults and children (8th ed.). Elsevier Health Sciences (US).

Yap, T. S., Jiwane, A., Belessis, Y., & Ooi, C. Y. (2014). Colonic atresia presenting as neonatal bowel obstruction in cystic fibrosis. Journal of Pediatric Gastroenterology and Nutrition, 58(4), e37–e38. https://doi.org/10.1097/mpg.0b013e3182769768

RE: Group A: Cystic Fibrosis

Great post Scot. Cystic fibrosis is a chronic lung disease with systemic inflammation. (Ozturk et al, 2020). A study by Wadood and Solan (2014) shows that for people having cystic fibrosis, an aberrant gene causes the cells to secrete thick and sticky mucus, which clogs the different passageways or ducts in the body. Specifically, the defect is in the “cystic fibrosis transmembrane conductance regulator” (CFTR) gene, which is responsible for the movement of water and salt in and out the body cell.

Having such mutation can eventually lead to infections, respiratory failure and/or malnutrition can result. Particularly, in the digestive system, the abnormal mucus buildup can alter absorption and flow of digestive enzymes necessary for the absorption of food nutrients. Hence, patients can experience constipation, swollen abdomen, poor weight gain among others.

Certainly, the mother carries the defective cystic fibrosis gene. If both her partner carries the defective gene, she will have a 25% chance of producing a child with such disorder again in each pregnancy.

References Alterations in Cellular Processes NURS 6501 Discussion

Abdul Wadood Mohamed and Matthew Solan. (2014, February 19). Cystic Fibrosis: Causes, Diagnosis, and Treatment. Retrieved September 03, 2020, from https://www.healthline.com/health/cystic-fibrosis

ÖZTÜRK, G. K., EŞKİ, A., ÇELİK, F. Ç., CONKAR, S., GÜLEN, F., DEMİR, E., & KESKİNOĞLU, A. (2020). Prospective evaluation of vascular changes in acute respiratory infections in children with cystic fibrosis. Turkish Journal of Medical Sciences50(4), 1007–1014. https://doi-org.ezp.waldenulibrary.org/10.3906/sag-2002-61

Name:  Discussion Rubric

  Excellent

90–100

Good

80–89

Fair

70–79

Poor

0–69

Main Posting:

Response to the Discussion question is reflective with critical analysis and synthesis representative of knowledge gained from the course readings for the module and current credible sources.

40 (40%) – 44 (44%)

Thoroughly responds to the Discussion question(s).

Is reflective with critical analysis and synthesis representative of knowledge gained from the course readings for the module and current credible sources.

No less than 75% of post has exceptional depth and breadth.

Supported by at least three current credible sources.

35 (35%) – 39 (39%)

Responds to most of the Discussion question(s).

Is somewhat reflective with critical analysis and synthesis representative of knowledge gained from the course readings for the module.

50% of the post has exceptional depth and breadth.

Supported by at least three credible references.

31 (31%) – 34 (34%)

Responds to some of the Discussion question(s).

One to two criteria are not addressed or are superficially addressed.

Is somewhat lacking reflection and critical analysis and synthesis.

Somewhat represents knowledge gained from the course readings for the module.

Cited with fewer than two credible references.

0 (0%) – 30 (30%)

Does not respond to the Discussion question(s).

Lacks depth or superficially addresses criteria.

Lacks reflection and critical analysis and synthesis.

Does not represent knowledge gained from the course readings for the module.

Contains only one or no credible references.

Main Posting:

Writing

6 (6%) – 6 (6%)

Written clearly and concisely.

Contains no grammatical or spelling errors.

Adheres to current APA manual writing rules and style.

5 (5%) – 5 (5%)

Written concisely.

May contain one to two grammatical or spelling errors.

Adheres to current APA manual writing rules and style.

4 (4%) – 4 (4%)

Written somewhat concisely.

May contain more than two spelling or grammatical errors.

Contains some APA formatting errors.

0 (0%) – 3 (3%)

Not written clearly or concisely.

Contains more than two spelling or grammatical errors.

Does not adhere to current APA manual writing rules and style.

Main Posting:

Timely and full participation

9 (9%) – 10 (10%)

Meets requirements for timely, full, and active participation.

Posts main Discussion by due date.

8 (8%) – 8 (8%)

Meets requirements for full participation.

Posts main Discussion by due date.

7 (7%) – 7 (7%)

Posts main Discussion by due date.

0 (0%) – 6 (6%)

Does not meet requirements for full participation.

Does not post main Discussion by due date.

First Response:

Post to colleague’s main post that is reflective and justified with credible sources.

9 (9%) – 9 (9%)

Response exhibits critical thinking and application to practice settings.

Responds to questions posed by faculty.

The use of scholarly sources to support ideas demonstrates synthesis and understanding of learning objectives.

8 (8%) – 8 (8%)

Response has some depth and may exhibit critical thinking or application to practice setting.

7 (7%) – 7 (7%)

Response is on topic and may have some depth.

0 (0%) – 6 (6%)

Response may not be on topic and lacks depth.

First Response:

Writing

6 (6%) – 6 (6%)

Communication is professional and respectful to colleagues.

Response to faculty questions are fully answered, if posed.

Provides clear, concise opinions and ideas that are supported by two or more credible sources.

Response is effectively written in standard, edited English.

5 (5%) – 5 (5%)

Communication is mostly professional and respectful to colleagues.

Response to faculty questions are mostly answered, if posed.

Provides opinions and ideas that are supported by few credible sources.

Response is written in standard, edited English.

4 (4%) – 4 (4%)

Response posed in the Discussion may lack effective professional communication.

Response to faculty questions are somewhat answered, if posed.

Few or no credible sources are cited.

0 (0%) – 3 (3%)

Responses posted in the Discussion lack effective communication.

Response to faculty questions are missing.

No credible sources are cited.

First Response:

Timely and full participation

5 (5%) – 5 (5%)

Meets requirements for timely, full, and active participation.

Posts by due date.

4 (4%) – 4 (4%)

Meets requirements for full participation.

Posts by due date.

3 (3%) – 3 (3%)

Posts by due date.

0 (0%) – 2 (2%)

Does not meet requirements for full participation.

Does not post by due date.

Second Response:
Post to colleague’s main post that is reflective and justified with credible sources.
9 (9%) – 9 (9%)

Response exhibits critical thinking and application to practice settings.

Responds to questions posed by faculty.

The use of scholarly sources to support ideas demonstrates synthesis and understanding of learning objectives.

8 (8%) – 8 (8%)

Response has some depth and may exhibit critical thinking or application to practice setting.

7 (7%) – 7 (7%)

Response is on topic and may have some depth.

0 (0%) – 6 (6%)

Response may not be on topic and lacks depth.

Second Response:
Writing
6 (6%) – 6 (6%)

Communication is professional and respectful to colleagues.

Response to faculty questions are fully answered, if posed.

Provides clear, concise opinions and ideas that are supported by two or more credible sources.

Response is effectively written in standard, edited English.

5 (5%) – 5 (5%)

Communication is mostly professional and respectful to colleagues.

Response to faculty questions are mostly answered, if posed.

Provides opinions and ideas that are supported by few credible sources.

Response is written in standard, edited English.

4 (4%) – 4 (4%)

Response posed in the Discussion may lack effective professional communication.

Response to faculty questions are somewhat answered, if posed.

Few or no credible sources are cited.

0 (0%) – 3 (3%)

Responses posted in the Discussion lack effective communication.

Response to faculty questions are missing.

No credible sources are cited.

Second Response:
Timely and full participation
5 (5%) – 5 (5%)

Meets requirements for timely, full, and active participation.

Posts by due date.

4 (4%) – 4 (4%)

Meets requirements for full participation.

Posts by due date.

3 (3%) – 3 (3%)

Posts by due date.

0 (0%) – 2 (2%)

Does not meet requirements for full participation.

Does not post by due date.

Total Points: 100

Name:  Discussion Rubric

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