In this exercise, you will complete a 5-essay type question Knowledge Check to gauge your understanding of this module\u2019s content. \u202f<\/span>\u00a0<\/span><\/p>\n Possible topics covered in this Knowledge Check include:<\/span>\u00a0<\/span><\/p>\n Three basic bone-formations:<\/span>\u00a0<\/span><\/p>\n \u00a0<\/span>Be sure to review the Learning Resources before completing this activity. <\/span> WEEKLY RESOURCES<\/span><\/b><\/a>\u00a0<\/span><\/p>\n Complete <\/span><\/b>the Knowledge Check\u202fby Day 7 of Week 7.<\/span>\u00a0<\/span><\/p>\n \u00a0<\/span><\/p>\n This quiz was locked Apr 16 at 10:59pm.\u00a0<\/span>\u00a0<\/span><\/p>\n *<\/span><\/i> Some questions not yet graded\u00a0<\/span>\u00a0<\/span><\/p>\n Correct answers will be available on Apr 19 at 10:59pm.\u00a0<\/span>\u00a0<\/span><\/p>\n Score for this quiz: 0 out of 20 *\u00a0<\/span>\u00a0<\/span><\/p>\n Submitted Apr 14 at 2:33am\u00a0<\/span>\u00a0<\/span><\/p>\n This attempt took 2,878 minutes.\u00a0<\/span>\u00a0<\/span><\/p>\n A\u202f68-year-old\u202fobese male presents to the clinic with a\u202f3-day\u202fhistory of fever with chills, and\u202fLt. great toe pain that has gotten progressively worse. Patient states this is the first time that this has\u202fhappened,\u202fand nothing has made it better and walking on\u202fhis right foot makes it worse.\u202fHe has tried\u202facetaminophen,\u202fbut it did not help. He\u202ftook several ibuprofen\u202ftablets\u202flast night which did give him a bit of relief.\u202f<\/span>\u00a0<\/span><\/p>\n HPI: hypertension treated with Lisinopril\/HCTZ\u202f.\u00a0<\/span>\u00a0<\/span><\/p>\n SH: Denies smoking. Drinking: \u201ca fair amount of red wine\u201d every week.\u202fGeneral appearance: Ill appearing male\u202fwho sits with\u202fhis\u202fright foot elevated.\u202f<\/span>\u00a0<\/span><\/p>\n PE: \u202fremarkable for a temp of 100.2, pulse 106, respirations\u202f20 and BP 158\/92. Right great toe (first\u202fmetatarsal\u202fphalangeal [MTP])\u202fnoticeably swollen and red. Unable to palpate to assess range of motion due to extreme pain.\u202fCBC\u202fand\u202fComplete metabolic profile revealed\u202fWBC 15,000 mm<\/span>3<\/span>\u202fand\u202furic acid 9.0 mg\/dl.\u00a0<\/span>\u00a0<\/span><\/p>\n Diagnoses the patient with acute gout.<\/span>\u00a0<\/span><\/p>\n Question:<\/span><\/b>\u00a0<\/span><\/p>\n Explain the pathophysiology of gout.<\/span><\/i>\u00a0<\/span><\/p>\n \u00a0<\/span><\/p>\n Your Answer:\u00a0<\/span>\u00a0<\/span><\/p>\n Gout is a common chronic condition that arises from the deposition of monosodium urate crystals in the non-articular and articular structures. The pathophysiology of gout begins with hyperuricemia. Hyperuricemia refers to the accumulation of serum urates due to factors such as intake of high-purine diet and alcohol intake. The kidneys and gut regulate urate excretion. Any problem with the gut or kidneys results in urine buildup in serum. The accumulation of urates results in monosodium urate deposition in the small joints, which may progress to gout. The monosodium crystals have damage-associated molecules that stimulate innate inflammatory responses. For example, monosodium urate crystals active NLRP3 inflammasome in the monocytes and macrophages leading to the initiation of gout flares (Dalbeth et al., 2021; Narang &Dalbeth, 2020). There is also the activation of TLR2 and TLR4 inflammatory components that cause inflammation in gout. \u202f\u202f\u202f\u202f\u202f\u202f\u202f\u202f\u202f\u202f\u202f\u202f\u202f\u202f<\/span>\u00a0<\/span><\/p>\n The next phase in gout is the development of tophi, structural joint damage, and synovitis. Tophi represents the foreign-body inflammatory response to the deposited monosodium urate crystals. There is also the structural damage of the joints alongside bone erosion and cartilage damage in the advanced stages of the disease. The damage develops from the high number of bone-resorbing osteoclasts that accelerate bone and joint damage. The monosodium urate crystals also reduce the availability of the osteoclasts as well as their function. The reduction causes a shift in the functioning of the osteocytes to favor inflammatory processes and bone resorption (Dalbeth et al., 2021). The above processes contribute to the three stages of gout development. The stages include the asymptomatic stage where there are no gout symptoms, acute gouty arthritis, where symptoms appear and tophi stage.\u00a0<\/span>\u00a0<\/span><\/p>\n Dalbeth, N., Gosling, A. L., Gaffo, A., & Abhishek, A. (2021). Gout. <\/span>The Lancet<\/span><\/i>, <\/span>397<\/span><\/i>(10287), 1843\u20131855. https:\/\/doi.org\/10.1016\/S0140-6736(21)00569-9<\/a><\/span>\u00a0<\/span><\/p>\n\n
\n
\n
Resources<\/span><\/b>\u00a0<\/span><\/h2>\n
\nClick the weekly resources link to access the resources.\u202f<\/span>\u00a0<\/span><\/p>\nBy Day 7 of Week 7<\/span><\/b>\u00a0<\/span><\/h2>\n
![\"NURS](\"http:\/\/nursingassignmentcrackers.com\/wp-content\/uploads\/2024\/01\/Capture-10-4-300x118.png\")
Attempt History<\/span><\/b>\u00a0<\/span><\/h2>\n
\n\n
\n \u00a0<\/span><\/td>\n Attempt<\/span><\/b>\u00a0<\/span><\/td>\n Time<\/span><\/b>\u00a0<\/span><\/td>\n Score<\/span><\/b>\u00a0<\/span><\/td>\n<\/tr>\n \n LATEST\u00a0<\/span><\/b>\u00a0<\/span><\/td>\n Attempt 1\u00a0<\/span><\/a>\u00a0<\/span><\/td>\n 2,878 minutes\u00a0<\/span>\u00a0<\/span><\/td>\n 0 out of 20 *\u00a0<\/span>\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n A Sample Answer For the Assignment: NURS 6501 Neurological and Musculoskeletal Disorders<\/strong><\/h2>\n
Title: NURS 6501 Neurological and Musculoskeletal Disorders<\/strong><\/h2>\n
Scenario 1: Gout<\/span><\/i><\/b>\u00a0<\/span><\/h3>\n
References<\/span><\/b>\u00a0<\/span><\/h2>\n