Before submitting your final assignment, you can check your draft for authenticity. To check your draft, access the\u00a0Turnitin Drafts<\/strong>\u00a0from the\u00a0Start Here<\/strong>\u00a0area.<\/p>\n

\n
1. To submit your completed assignment, save your Assignment as\u00a0MD1Assgn_LastName_Firstinitial<\/strong><\/li>\n
2. Then, click on\u00a0Start Assignment<\/strong>\u00a0near the top of the page.<\/li>\n
3. Next, click on\u00a0Upload File<\/strong>\u00a0and select\u00a0Submit Assignment<\/strong>\u00a0for review.<\/li>\n<\/ol>\n

   A Sample Answer For the Assignment:\u00a0NURS 6501 Pathophysiology Discussion Week 1 Case Study\u00a0<\/strong><\/h2>\n

   Title:\u00a0NURS 6501 Pathophysiology Discussion Week 1 Case Study\u00a0<\/strong><\/h2>\n

   The case study depicts an 83-year-old resident who presents to the ED with generalized edema of extremities and abdomen. The medical history reveals the patient has a history of malabsorption syndrome and difficulty eating secondary to lack of dentures. The patient has been diagnosed with protein malnutrition.\u00a0\u00a0<\/span>\u00a0<\/span><\/p>\n

   The Role Genetics Plays In the Disease<\/span><\/b>\u00a0<\/span><\/h2>\n

   The patient developed protein malnutrition secondary to malabsorption syndrome, which results in i<\/span>mpaired nutrient absorption. Genetics plays a role in Malabsorption syndrome as the defects in the absorption process can result from an inherited disease of the mucosa and congenital defects in the intestinal membrane transport systems (<\/span>Zuvarox & Belletieri, 2020)<\/span>. For instance, mutations in the MTP gene result in Abetalipoproteinemia characterized by defective apoproteins, which impair chylomicron packaging and secretion into the lymphatics.<\/span>\u00a0<\/span><\/p>\n

   An important gene associated with protein malnutrition is Albumin. Its related pathways and superpathways include Folate Metabolism and FOXA2 and FOXA3 transcription factor networks (<\/span>Benjamin & Lappin, 2019)<\/span>. Genetic defects in either of these pathways are associated with the altered metabolism of proteins resulting in depletion of albumin and eventually protein malnutrition.\u00a0\u00a0<\/span>\u00a0<\/span><\/p>\n

   Why the Patient Is Presenting With the Specific Symptoms Described<\/span><\/b>\u00a0<\/span><\/h2>\n

   Protein malnutrition is characterized by peripheral edema in a patient suffering from starvation. <\/span>The patient presents with generalized edema of extremities and abdomen, which is attributed to <\/span>a loss of fluid balance between hydrostatic and oncotic pressures across capillary blood vessel walls (<\/span>Benjamin & Lappin, 2019)<\/span>. Normally, Albumin concentration maintains the oncotic pressure, which allows the body to keep fluids within the vasculature. A patient with Protein malnutrition has profoundly low levels of albumin and, as a result, is intravascularly depleted (<\/span>Benjamin & Lappin, 2019)<\/span>. Subsequently, antidiuretic hormone levels rise in response to hypovolemia, resulting in edema. Plasma renin also responds aggressively, resulting in sodium retention and ultimately generalized edema.<\/span>\u00a0<\/span><\/p>\n