A Sample Answer For the Assignment: NR 507 Week 2 Discussion 1<\/strong><\/h2>\n

Title: NR 507 Week 2 Discussion 1<\/strong><\/h2>\n

In addition to the textbook, utilize at least one peer-reviewed, evidence based resource to develop your post.<\/span><\/b>\u00a0<\/span><\/h3>\n

What is the etiology of cystic fibrosis?<\/span><\/b>\u00a0<\/span><\/h3>\n

This topic is of great interest to me because of this subject that I will be doing my presentation on, so I did a detailed search. The peer review article revealed that according to Munder& Tummler (2015), cystic fibrosis lung disease result from impaired chloride and bicarbonate epithelial transport, defective mucociliary transport, and acidification of the airway-surface liquid. In many ways, the pathophysiological process differs according to the different evidenced-based practice. \u201cThe pathophysiology of cystic fibrosis is deduced from the loss or dysfunction of CFTR in the apical epithelial membrane\u201d Stoltz, (2015). The contributing factor is an attenuated bacteria-killing capability has reported in monocytes and macrophages isolated from people with cystic fibrosis.<\/span>\u00a0<\/span><\/p>\n

The response to the peer review is\u201d We agree with Munder and T\u00fcmmler that abnormal function in myeloid cells (i.e., neutrophils, monocytes, or macrophages) may contribute to impaired host defense in cystic fibrosis.\u201d Stoltz, 2015. The article contains other pertinent information to describe the depth of this disease. \u201cSpecific cell types involved (monocytes, neutrophils, or macrophages) and proposed mechanisms for defects (e.g., organelle acidification, complement-mediated phagocytosis, and intraphagosomal production of hypochlorous acid) vary substantially among studies.\u201d Stoltz (2015).\u202f<\/span>\u00a0<\/span><\/p>\n

Describe in detail the pathophysiological process of cystic fibrosis.<\/span><\/b>\u00a0<\/span><\/h3>\n

Cystic fibrosis is the abnormal secretions that obstruct the respiratory, digestive, and reproductive tract.\u202f According to (McCance et al., 2013) research shows that there may be additional CF-associated primary defects, such as a natural proinflammatory state and abnormal local immune defenses in the lungs. \u201cCystic fibrosis is also associated with cystic fibrosis transmembrane conductance regulator (CFTCR) gene mutation results in the abnormal expression of cystic fibrosis transmembrane conductance regulator (CFTCR) protein, which is a cyclic adenosine monophosphate (cAMP)\u2013activated chloride channel present on the surface of many types of epithelial cells.\u201d (McCance et al., 2013). \u202fThese cells include the lining of the airways, bile ducts, the pancreas, sweat glands, and the vas deferens. Even though cystic fibrosis affects multisystem it ultimately most often affects the lung, which is the most critical site of involvement that leads to respiratory failure and death.\u202f<\/span>\u00a0<\/span><\/p>\n

Identify hallmark signs identified from the physical exam and symptoms.<\/span><\/b><\/h3>\n

Click here to ORDER an A++ paper from our Verified MASTERS and DOCTORATE WRITERS:NR 507 Week 2 Discussion 1\u00a0<\/strong><\/a><\/em><\/span><\/h3>\n