NUR 550 Translational Research Framework and Legal/ Ethical Considerations

Sample Answer for NUR 550 Translational Research Framework and Legal/ Ethical Considerations Included After Question

Topic 3 DQ 1

Description:

Discuss the ethical guidelines that would need to be implemented when conducting translational research. What are the ethical and legal considerations related to translating research into practice? Discuss what steps you would take as a member of a translational research team in order to establish ethical guidelines for conducting translational research.

A Sample Answer For the Assignment: NUR 550 Translational Research Framework and Legal/ Ethical Considerations

Title: NUR 550 Translational Research Framework and Legal/ Ethical Considerations

All healthcare providers must act in an ethical manner.  Ethics should be at the core of everything we do and be a part of every decision that we make while keeping in mind the best interests of the patient (DeNisco, 2021).  Ethics in translational research can be tricky due to the nature of what is being researched.  Translational research is research that studies how evidence-based interventions are translated to real-world clinical settings (Melnyk, 2019).  However, to bring that research into the real-world multiple phases of testing must take place.  At any point during the different phases of translational research, harm can be done to either animals or humans.  This is where ethics in translational research can become tricky. 

While the intent of any translational research study is to have a good outcome that is not always the case.  The researchers must weigh the risks and benefits to the study participants versus the risks and benefits to the greater good of all people.  Legal and ethical guidelines are standard practice for all research studies and must be followed by all team members.  I think that as part of a translational research team the most important thing to ensure that all team members are following the proper protocols, and legal and ethical guidelines.  

References

DeNisco, S. M. (Ed.). (2021). Advanced practice nursing: Essential knowledge for the profession (4th ed.). Jones & Bartlett Learning. ISBN-13: 978128417612

Melnyk, B. M., & Fineout-Overholt, E. (2019). Evidence-based practice in nursing and healthcare: A guide to best practice (4th ed.). Wolters Kluwer. ISBN-13: 9781496384539

A Sample Answer 2 For the Assignment: NUR 550 Translational Research Framework and Legal/ Ethical Considerations

Title: NUR 550 Translational Research Framework and Legal/ Ethical Considerations

Practicing ethical guidelines when conducting and reporting research studies, whether translational or not, is essential to establishing research validity. Researchers must adhere to ethical guidelines issued by regulatory bodies and committees to ascertain the safety of participants. Translational research is unique since it focuses on transfer of scientific knowledge into clinical practice and mainly involves and targets human subjects (Riva & Petrini, 2019). Therefore, ethical and legal guidelines are imperatives for those conducting these studies. The three main principles include respect of persons, beneficence and justice. It is essential to comply with the ethical principles to protect the dignity, rights, and welfare of the research subjects.

The researchers must also consider compliance to the legal provisions as stipulated by laws like HIPAA and HITECH on aspects like privacy, confidentiality, and ensuring that participants are not minors. Legal considerations also require the attainment of informed consent from the participants. The implication is that participants should know the risks and benefits involved in a study for them to make informed decisions (Daverio, 2019). The researchers must provide all the necessary information, including the side effects of a study for potential subjects to make informed decisions and offer their consent. Minors do not have autonomy and individuals with disabilities should also be considered as vulnerable.

Members of translational research teams should ensure that they adhere to the existing ethical guidelines and legal requirements when carrying out studies. These entail having approval from Institutional Revie Boards, using biomedical principles and ascertaining that there is confidentiality, privacy through applying a risk-benefit approach (Riva & Petrini, 2019). Ethical considerations and legal requirements will ensure the validity and reliability of research and its findings.

References

Daverio, M. (2019). Informed Consent in Translational/Clinical Research. Ethical Issues

According to International Guidelines. BioLaw Journal-Rivista di BioDiritto, 16(1S), 123-138.

Riva, L. & Petrini, C. (2019). A few ethical issues in translational research for gene and cell

therapy. Journal of Translational Medicine, 17(395). DOI: https://doi.org/10.1186/s12967-019-02154-5

Topic 3 DQ 1

Description:

Topic 3 DQ 2

Description:

Discuss the role of the Institutional Review Board. Discuss ethical research considerations specific to population health. How are respect for the persons, potential benefits and burdens of the research, and justice kept in balance? Provide an example.
Topic 3 Participation
Description:
NA
Topic 3: Translational Research Framework and Legal and Ethical Considerations
Description
Objectives:

1. Discuss ethical guidelines for conducting translational research.
2. Examine ethical considerations related to translating research into practice .
3. Examine legal considerations related to translating research into practice.
4. Discuss ethical research considerations specific to population health.
Study Materials
Advanced Practice Nursing: Essential Knowledge for the Profession
Description:
Read Chapter 26 in Advanced Practice Nursing: Essential Knowledge for the Profession.

NUR 550 Translational Research Framework and Legal Ethical Considerations

Population Health: Creating a Culture of Wellness
Description:
Read Chapter 10 in Population Health: Creating a Culture of Wellness.
A Few Ethical Issues in Translation Research for Gene and Cell Therapy
Description:
Read “A Few Ethical Issues in Translation Research for Gene and Cell Therapy,” by Riva and Petrini, from Journal of Translational Medicine (2019).
The Underappreciated and Misunderstood PICOT Question: A Critical Step in EBP Process.

Click here to ORDER an A++ paper from our Verified MASTERS and DOCTORATE WRITERS: NUR 550 Translational Research Framework and Legal/ Ethical Considerations

Description:
Read “The Underappreciated and Misunderstood PICOT Question: A Critical Step in EBP Process,” by Gallagher-Ford and Melnyk, from Worldviews on Evidence-Based Nursing (2019).
Life After PICOT: Taking the Next Step in a Clinical Inquiry Project
Description:
Read “Life After PICOT: Taking the Next Step in a Clinical Inquiry Project,” by Granger, from AACN Advanced Critical Care (2020).
The Belmont Report
Description:
Read “The Belmont Report,” by The National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research, located on the U.S. Department of Health and Human Services website (1979).
PICO: A Model for Evidence-Based Research
Description:
View “PICO: A Model for Evidence-Based Research,” by Binghamton University Libraries, located on YouTube (2017).
What is Evidence-Based Practice?
Description:
View “What is Evidence-Based Practice?” by Lippincott NursingCenter.com, located on YouTube (2016).
Course Code Class Code Assignment Title Total Points
NUR-550 NUR-550-O503 Evidence-Based Practice Project Proposal: PICOT 75.0
Criteria Percentage Unsatisfactory (0.00%) Less Than Satisfactory (80.00%) Satisfactory (88.00%) Blank (92.00%) Blank (100.00%)
Content 100.0%
Population (Revision) 7.0% The population is not described, or the required revisions were not made for the population description. NA Revisions were made accordingly for the population description, but some information or detail is needed for accuracy or clarity. NA The population is thoroughly and accurately described. No revision was needed.
Intervention (Revision) 8.0% The proposed intervention is not described, or the required revisions were not made for the described intervention. NA Revisions were made accordingly for the proposed intervention, but some information or detail is needed for accuracy or clarity. NA The proposed intervention is clearly described and relevant to the nursing practice problem and population. No revision was needed.
Comparison 10.0% A description of the comparison information is not included. A description of the comparison information is incomplete or incorrect. A description of the comparison information is included but lacks evidence and measurable outcomes. A description of the comparison information is complete and includes sufficient evidence and measurable outcomes. A description of the comparison information is extremely thorough with substantial evidence and measurable outcomes.
Outcome 10.0% A description of the outcome is not included. A description of the outcome is not included. A description of the outcome is included but lacks evidence. A description of the outcome is complete and includes sufficient evidence. A description of the outcome is extremely thorough with substantial evidence
Timeline 10.0% A description of the timeline is not included. A description of the timeline is incomplete or incorrect. A description of the timeline is included but lacks evidence. A description of the timelines is complete and includes sufficient evidence. A description of the timeline is extremely thorough with substantial evidence.
PICOT 20.0% The PICOT statement is omitted. The PICOT statement is incomplete. The PICOT statement is presented but there some inaccuracies. The PICOT statement is presented. Some detail is needed. The PICOT statement concisely and accurately describes the problem.
Problem Statement 20.0% A problem statement is not included. The problem statement is incomplete. The problem statement is generally presented. There are some inaccuracies. More support is needed to justify or rationalize the problem. The problem statement is presented. Adequate support is provided to justify or rationalize the problem. The problem statement concisely describes the issue using strong support to rationalize and justify the problem.
Required Sources 5.0% Sources are not included. Number of required sources is only partially met. Number of required sources is met, but sources are outdated or inappropriate. Number of required sources is met. Sources are current, but not all sources are appropriate for the assignment criteria and nursing content. Number of required resources is met. Sources are current and appropriate for the assignment criteria and nursing content.
Mechanics of Writing (includes spelling, punctuation, grammar, and language use) 5.0% Surface errors are pervasive enough that they impede communication of meaning. Inappropriate word choice or sentence construction is employed. Frequent and repetitive mechanical errors distract the reader. Inconsistencies in language choice (register) or word choice are present. Sentence structure is correct but not varied. Some mechanical errors or typos are present, but they are not overly distracting to the reader. Correct and varied sentence structure and audience-appropriate language are employed. Prose is largely free of mechanical errors, although a few may be present. The writer uses a variety of effective sentence structures and figures of speech. The writer is clearly in command of standard, written, academic English.
Documentation of Sources (citations, footnotes, references, bibliography, etc., as appropriate to assignment and style) 5.0% Sources are not documented. Documentation of sources is inconsistent or incorrect, as appropriate to assignment and style, with numerous formatting errors. Sources are documented, as appropriate to assignment and style, although some formatting errors may be present. Sources are documented, as appropriate to assignment and style, and format is mostly correct. Sources are completely and correctly documented, as appropriate to assignment and style, and format is free of error.

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The university’s policy on late assignments is 10% penalty PER DAY LATE. This also applies to late DQ replies.

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Questions to Instructor Forum: This is a great place to ask course content or assignment questions. If you have a question, there is a good chance one of your peers does as well. This is a public forum for the class.

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Important information for writing discussion questions and participation

Welcome to class

Hello class and welcome to the class and I will be your instructor for this course. This is a -week course and requires a lot of time commitment, organization, and a high level of dedication. Please use the class syllabus to guide you through all the assignments required for the course. I have also attached the classroom policies to this announcement to know your expectations for this course. Please review this document carefully and ask me any questions if you do. You could email me at any time or send me a message via the “message” icon in halo if you need to contact me. I check my email regularly, so you should get a response within 24 hours. If you have not heard from me within 24 hours and need to contact me urgently, please send a follow up text to

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Plagiarism is highly prohibited. Please ensure you are citing your sources correctly using APA 7th edition. All assignments including discussion posts should be formatted in APA with the appropriate spacing, font, margin, and indents. Any papers not well formatted would be returned back to you, hence, I advise you review APA formatting style. I have attached a sample paper in APA format and will also post sample discussion responses in subsequent announcements.

Your initial discussion post should be a minimum of 200 words and response posts should be a minimum of 150 words. Be advised that I grade based on quality and not necessarily the number of words you post. A minimum of TWO references should be used for your initial post. For your response post, you do not need references as personal experiences would count as response posts. If you however cite anything from the literature for your response post, it is required that you cite your reference. You should include a minimum of THREE references for papers in this course. Please note that references should be no more than 5 years old except recommended as a resource for the class. Furthermore, for each discussion board question, you need ONE initial substantive response and TWO substantive responses to either your classmates or your instructor for a total of THREE responses. There are TWO discussion questions each week, hence, you need a total minimum of SIX discussion posts for each week. I usually post a discussion question each week. You could also respond to these as it would count towards your required SIX discussion posts for the week.

I understand this is a lot of information to cover in 5 weeks, however, the Bible says in Philippians 4:13 that we can do all things through Christ that strengthens us. Even in times like this, we are encouraged by God’s word that we have that ability in us to succeed with His strength. I pray that each and every one of you receives strength for this course and life generally as we navigate through this pandemic that is shaking our world today. Relax and enjoy the course!

Hi Class,

Please read through the following information on writing a Discussion question response and participation posts.

Contact me if you have any questions.

Important information on Writing a Discussion Question

Your response needs to be a minimum of 150 words (not including your list of references)
There needs to be at least TWO references with ONE being a peer reviewed professional journal article.
Include in-text citations in your response
Do not include quotes—instead summarize and paraphrase the information
Follow APA-7th edition
Points will be deducted if the above is not followed

Participation –replies to your classmates or instructor

A minimum of 6 responses per week, on at least 3 days of the week.
Each response needs at least ONE reference with citations—best if it is a peer reviewed journal article
Each response needs to be at least 75 words in length (does not include your list of references)
Responses need to be substantive by bringing information to the discussion or further enhance the discussion. Responses of “I agree” or “great post” does not count for the word count.
Follow APA 7th edition
Points will be deducted if the above is not followed
Remember to use and follow APA-7th edition for all weekly assignments, discussion questions, and participation points.
Here are some helpful links
Student paper example
Citing Sources
The Writing Center is a great resource

A Sample Answer 3 For the Assignment: NUR 550 Translational Research Framework and Legal/ Ethical Considerations

Title: NUR 550 Translational Research Framework and Legal/ Ethical Considerations

As with any research or experiments conducted on the human body, translational research and studies can pose many ethical concerns that one should be aware of before implementation. Ensuring informed consent is the responsibility of any researcher, especially those in the T1 and T2 phase of translational research studies (Mandal, Ponnambath, & Parija, 2017) Legal implications may even arise if participants are not well informed of the process and all the risks/benefits that may exist.  By ensuring patients are giving their completely informed consent, researchers can eliminate any misconceptions participants may have about the therapeutic benefits of the study that may lead them to participate when they might not have otherwise (Mandal, Ponnambath, & Parija, 2017). Conflicts of interest are another ethical concern in translational research, especially if researchers have anything to gain financially from the study. Social injustice is another ethical concern, especially dealing with population health issues. One example of this might be a resource-rich country conducting a study in a resource-poor country, but the benefits to the health of the population in the resource-poor country might be minimal, or products being studied might be too expensive for participants or the rest of the population to even be able to afford after the study has concluded (Mandal, Ponnambath, & Parija, 2017). This is one area I think it’s important to be mindful of as researchers design studies and where to conduct them. If I were to design a research study and assemble a team, I would ensure that the study was conducted with the goal of improving a problem that is a burden to the health of the population included in the study, and that the interventions or products being developed would actually be affordable to those within that population. I feel this approach would be best to help improve the health of the population in the study.

References:

Mandal, J., Ponnambath, D., & Parija, S. (2017). Ethics of translational medical research. Tropical Parasitilogy, 7(2), 62-64. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652056/