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NUR 550 DQ: Translational Research in Population Health Problems

NUR 550 DQ Translational Research in Population Health Problems

Re: Topic 1 DQ 2

When looking through the GCU library for an interesting study containing translational research, I found this study called “Enhanced differentiation of human dopaminergic neural cell model for preclinical translational research in Parkinson’s disease.” (Harischandra et. Al, 2020). This study states that there are treatment options out there for those patients with Parkinsons, like deep brain stimulation and medications like levodopa, but these treatments are only touching the surface of the issue at hand (Harischandra et. al, 2020). They state that for future (better) treatment for these patients they need to look at the dopaminergic neurons as well as the dopamine transporter (Harischandra, et. Al, 2020). They attempted to preform studies on rats but found that the cells differed in a way that would not give them accurate results (Harishchandra, et. Al, 2020). They then went on to utilize embryonic stem cells and developing these into LUHMES cells which more closely resembled the pathways they were trying to achieve (Harischandra, et. Al, 2020). By doing their experiments on these cells they are in the T1 transition, pre patient and practice, in the lab studying the real effects on the neural pathways (Translational Research, n.d.). I’m not going to lie the study is lengthy and the process they utilized involved a ton of chemicals and days of watching these cells develop into what they needed, but at the end of 5 days their processes had drastically increased the reuptake of dopamine in the cells (Hasichandra, et. Al, 2020). Stem Cells are not always available for drug research so being able to develop these LUHMES cells to test on is great for the future of Parkinson’s research and for testing drugs (Harischandra et. Al, 2020).

 

Harischandra, D. S., Rokad, D., Ghaisas, S., Verma, S., Robertson, A., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2020). Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson’s disease. Biochimica et Biophysica Acta. Molecular Basis of Disease1866(4), 165533. https://doi-org.lopes.idm.oclc.org/10.1016/j.bbadis.2019.165533

Translational Research – Defining the “T’s” | Translational Cancer Research Network. (n.d.). Www.Tcrn.Unsw.Edu. Retrieved June 18, 2021, from http://www.tcrn.unsw.edu.au/translational-research-definitions

 

RESPOND HERE (150 WORDS, 2 REFERENCES)

This is insightfulSarah, the study, “Enhanced differentiation of human dopaminergic neural cell model for preclinical translational

NUR 550 DQ Translational Research in Population Health Problems

NUR 550 DQ Translational Research in Population Health Problems

research in Parkinson’s disease.” Contains translational research expressed in different ways. The study highlighted indicates different methods or options for managing or treating Parkinson’s (Harischandra et al., 2020). The article further elaborates that the approaches applied only touch on the surface of the issue that has been identified. From the research study highlighted, there is the application of T1 translational research. The approach that has been used has proved critical when it comes to the determination of the outcomes of the research process. From the study highlighted, it has been found that Parkinson’s is a disease or disorder that greatly impacts the functioning of the brain. The conditions often lead to stiffness, shaking, and difficulty with body balance, walking, as well as general coordination (Rubio et al., 2019). The study highlighted that the symptoms of Parkinson’s diseases normally start and progress gradually and worsen over time. As the disease progresses, there is always difficulty in talking and walking.

References

Harischandra, D. S., Rokad, D., Ghaisas, S., Verma, S., Robertson, A., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2020). Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson’s disease. Biochimica et Biophysica Acta. Molecular Basis of Disease1866(4), 165533. https://doi-org.lopes.idm.oclc.org/10.1016/j.bbadis.2019.165533

Rubio, I., Osuchowski, M. F., Shankar-Hari, M., Skirecki, T., Winkler, M. S., Lachmann, G., … & Bermejo-Martín, J. F. (2019). Current gaps in sepsis immunology: new opportunities for translational research. The Lancet Infectious Diseases19(12), e422-e436. https://www.sciencedirect.com/science/article/abs/pii/S1473309919305675

 

Re: Topic 1 DQ 2

Incidences of stroke in the U.S. have declined in the past few years for the first time in history. However, stroke incidence among older adults has always been higher than younger adults, especially older women (Portz et al., 2018). Older adults of 80 years and above make about 17% of all stroke patients and are at high risk of mortality and prolonged hospital stays (Portz et al., 2018). This journal is in phase T4 type of translational research, where the information obtained in the previous stages is disseminated and implemented. This translational research aimed to investigate the impact of physical fitness and exercises for older adults with chronic stroke. A large body of literature has examined the correlation between self-management intervention such as physical fitness and exercise and chronic stroke. For instance, Schmid et al. (2014) observed that patients with chronic stroke showed physical improvements like body balance after enrolling in a yoga program that involved physical activities such as walking.

Based on the previous literature, Portz et al. (2018) used the information to investigate whether physical fitness and exercise would be used as a clinical intervention for managing chronic stroke. After implementing the information, Portz et al. (2018) found that it is essential for health care professionals to incorporate self-management interventions such as physical fitness and exercise in managing chronic stroke among older adults. This will improve their quality of life, strength, and endurance by incorporating yoga practice. Furthermore, this kind of research will encourage more health care researchers to conduct translational research to reach phase 4 (T4), where yoga practice can be used as an evidence-based intervention for chronic stroke.

 

References

Portz, J. D., Waddington, E., Atler, K. E., Van Puymbroeck, M., & Schmid, A. A. (2018). Self-management and yoga for older adults with chronic stroke: A mixed-methods study of physical fitness and physical activity. Clinical Gerontologist, 41(4), 374–381. https://doi-org.lopes.idm.oclc.org/10.1080/07317115.2016.1252453

Schmid, A. A., Miller, K. K., Van Puymbroeck, M., & DeBaun-Sprague, E. (2014). Yoga leads to multiple physical improvements after stroke, a pilot study. Complementary Therapies in Medicine, 22(6), 994–1000. https://doiorg.lopes.idm.oclc.org10.1016/j.ctim.2014.09.005

Topic 1 DQ 2

Description:

Using the GCU Library (notably the GCU Library: Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focus on translational research. Select a population health problem or issue of interest from the available studies. What type of translational research is used for the study? Provide rationale as to why this is the best.

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Description:

Learners will select a valid nursing practice problem for an evidence-based practice project proposal. The project will be completed in sections, beginning in NUR-550 and culminating in a final written paper detailing the evidence-based practice proposal in NUR-590.

The purpose of this assignment is to select a relevant nursing practice problem for your evidence-based practice project proposal. To identify a relevant problem, consider problems generally faced in nursing practice (coordination of health care, assessment, education, patient
support, trauma prevention, recovery, health screenings, etc.). Use the “PICOT Draft” template to complete this assignment.

Use a national, state or local population health care database to research indicators of disparity. Choose a mortality/morbidity indicator to identify a clinical problem or issue that you want to explore pertaining to a population of focus. Use this indicator to begin to formulate a PICOT statement.

Refer to the “Evidence-Based Practice Project Proposal – Assignment Overview” document for an overview of the evidence-based practice project proposal assignments.

You are required to cite one peer-reviewed source to complete this assignment. Sources must be published within the last 5 years and appropriate for the assignment criteria and nursing content.

While APA style is not required for the body of this assignment, solid academic writing is expected, and documentation of sources should be presented using APA formatting guidelines, which can be found in the APA Style Guide, located in the Student Success Center.

This assignment uses a rubric. Please review the rubric prior to beginning the assignment to become familiar with the expectations for successful completion.

You are not required to submit this assignment to LopesWrite.

 

Description

 

Objectives:

1. Identify the different levels of translational research.
2. Differentiate translational research from evidence-based practice.
3. Discuss the application of translational research to population health management.
4. Evaluate sources of translational research.
5. Select a valid nursing practice problem for an evidence-based practice project proposal

Advanced Practice Nursing: Essential Knowledge for the Profession

Description:

Read Chapters 22 and 23 in Advanced Practice Nursing: Essential Knowledge for the Profession.

Evidence-Based Practice in Nursing and Healthcare

Description:

Read Chapter 1 in Evidence-Based Practice in Nursing and Healthcare.

World Health Organization (WHO)

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Description:

Explore the World Health Organization (WHO) website.

Centers for Disease Control and Prevention (CDC)

Description:

Explore the Centers for Disease Control and Prevention (CDC) website.

State and County Departments of Health

Description:

Explore the websites of your state and county departments of health and access mortality and morbidity data. The link to the Arizona Department of Health Services website is provided, but students living in other states should access their county and state departments.

Non-Communicable Diseases (NCD) Burden of Disease

Description:

Read “Non-Communicable Diseases (NCD) Burden of Disease,” by the U.S. Department of Health and Human Services, located on the Centers for Disease Control and Prevention website.

GCU Library: Nursing and Health Sciences Research Guide

Description:

Review the “Nursing and Health Sciences” research guide, located on the GCU Library website.

The Electronic Health Record: A Friend or Foe of Translational Research and Evidence-Based Practice?
Description:

Read “The Electronic Health Record: A Friend or Foe of Translational Research and Evidence-Based Practice?” by Chipps et al., from Worldviews on Evidence-Based Nursing (2019).

Evidence-Based Practice

Description:

Read “Evidence-Based Practice” by Melnyk and Fineout-Overholt, from Encyclopedia of Nursing Research (2017).

Translation Research in Practice: An Introduction

Description:

Read “Translation Research in Practice: An Introduction,” by Titler, from Online Journal of Issues in Nursing (2018).

On Biostatistics and Clinical Trials: PICO, PICOTS, PICOTT Framework for Clinical Questions as a Way to Design Clinical Trials
Description:

Read “PICO, PICOTS, PICOTT Framework for Clinical Questions as a Way to Design Clinical Trials,” by Deng, from
On Biostatistics and Clinical Trials (2020).

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