NUR 550 Discussion: Levels of Translational Research
Sample Answer for NUR 550 Discussion: Levels of Translational Research Included After Question
Topic 1 DQ 1
Description:
Identify the different levels of translational research. Explain how translational research is different from evidence-based practice and discuss its application to population health management.
A Sample Answer For the Assignment: NUR 550 Discussion: Levels of Translational Research
Title: NUR 550 Discussion: Levels of Translational Research
Population health management requires health care providers, people, and communities to apply up-to-date and relevant approaches to respond to current and emerging health problems. Amid this, discoveries of new approaches to health and strategies of enhancing health outcomes are vital. Translational research’s primary purpose is to produce more meaningful, applicable results that benefit human health directly (Titler, 2018). It comes in different levels whose purposes and outcomes vary. As Fort et al. (2017) explained, phase T1 involves testing findings from basic research for clinical applicability, T2 tests new interventions in controlled environments, and T3 explores ways of applying guidelines in general practice. T4 research examines factors and interventions influencing population health.
From a health perspective, translational research differs from evidence-based practice in meaning and application. To a considerable extent, translational research involves discovering new knowledge. Titler (2018) described it as a process for yielding knowledge and the potential for intervention. If differently stated, translational research generates knowledge to form the basis for clinical application. In health practice, evidence-based practice involves utilizing the most current research to improve patients’ health and safety (Chien, 2019). It is generally a problem-solving approach that combines best practices from research with clinical experience and patients’ preferences to enhance outcomes. In this case, translational research is the foundation of evidence-based practice.
Concerning application to population health management, population health improvement relies heavily on knowledge. Illnesses emerge over time, and illnesses’ dynamics change according to people’s age, gender, blood group, and living environments, among other factors. Such variations complicate public health, and optimal health cannot be achieved if health care providers rely on a general approach or primarily the present knowledge. Solution-driven discoveries must be made as time advances to respond to the emerging health challenges. Translational research generates new knowledge critical in managing population health.
References
Chien L. Y. (2019). Evidence-based practice and nursing research. The Journal of Nursing Research : JNR, 27(4), e29. https://doi.org/10.1097/jnr.0000000000000346
Fort, D. G., Herr, T. M., Shaw, P. L., Gutzman, K. E., & Starren, J. B. (2017). Mapping the evolving definitions of translational research. Journal of Clinical and Translational science, 1(1), 60-66. doi: 10.1017/cts.2016.10
Titler, M. G. (2018). Translation research in practice: An introduction. OJIN: The Online Journal of Issues in Nursing, 23(2). doi: 10.3912/OJIN.Vol23No02Man01
A Sample Answer 2 For the Assignment: NUR 550 Discussion: Levels of Translational Research
Title: NUR 550 Discussion: Levels of Translational Research
Translational research is a new concept in my view of the world, it is a fairly new concept, as nurses we hear the term evidence-based practice (EBP) and research. Translational research is often thought of as EPB, Translational research is the research of EBP studies as well as the study and translation of EBP interventions into practice (Melnyk & Fineout-Overholt, 2019) Translational research is as stated it translates how EBP “translates” into practice, evidence-based practice is a guide to practice, translation science is the translation to implement the evidence-based research into practice. (Tilter, 2018). Translation research has different components to implementation of preclinical studies, phase one small clinical trials, phase 2&3 larger clinical trials, outcomes from the clinical trials, them phase 5 population outcomes research- these phases offer a “bench to bedside” continuum (Tilter, 2018).
Gaps between the availability of evidence and the placing evidence into practice has shown to partner with poor outcomes by not enabling caregivers to place the evidence into practice. (Tilter, 2018)Transitional research has shown to be beneficial in-patient outcomes and health care management by translating the evidence into practice which improves patient outcomes by the utilization of the evidence. In my field of Labor and delivery I have seen this similar process in the abundance availability of research and evidence of the increased risk of hypertension in pregnancy. Yet the physicians I practice with implement in very many ways through lack of translation causing early inductions and higher risk to the infants. When implementing a new technology, evidence or practice it is important to understand the research and evidence behind it as well as how best to safely implement into practice. (Sung et al., 2020) Translation research is an exciting and has multiple opportunities to advance patient outcomes, as an upcoming APRN in a magnet hospital, utilizing this process with EBP will strongly improve patient care as well as nursing practice.
References
Melnyk, B. M., PhD, RN. APRN-CNP, FAANP, FNAP, FAAN, & Fineout-Overholt, E., PhD, RN, FNAP, FAAN. (2019). Evidence-Based Practice in Nursing& Healthcare A Guide to Best Practice (4th ed.). Wolters Kluwer.
Sung, V. W., MD MPH, Tulikangas, P., MD, Bradley, C. S., MD, MSCE, & Rideway, B., MD. (2020). Assessing and adopting New medical devices for Obstetric and Gynecologic care. ACOG, 135(4), 160–166. Retrieved May 26, 2021, from
Tilter, M. G. (2018). Translation Research in Practice: An Introduction. Online Journal of Issues in Nursing, 23(2). Retrieved June 16, 2021, from
A Sample Answer 3 For the Assignment: NUR 550 Discussion: Levels of Translational Research
Title: NUR 550 Discussion: Levels of Translational Research
As nurses, we all have heard about evidence-based practice and Florence Nightingale. Although back then, the term evidence-based practice was not a common phrase, that is exactly what Florence Nightingale was doing back then. She would examine and experiment with the sanitary conditions of the facilities and look at how it affected the patient’s outcomes (Mackey & Bassendowski, 2017). Translational research is more of a newer terminology. Although it can be confused with evidence-based practice, there is a key distinction. Evidence-based practice is the act of applying the evidence into everyday practice, whereas translational research is more the act of conducting the studies to find the best evidence (Titler, 2018).
There are strict guidelines when conducting translational research or what many of us know as clinical trials. There is phase process where in order to progress to the next phase of clinical trials, they must meet certain criteria. New drugs must undergo in vitro preclinical trials where they are testing it in a laboratory setting instead of human trials. Then they can proceed to in vivo studies where they are studying it in animals and small sample size of human trials (Eske, 2020). Once it has proven to be safe, then they can progress to a phase two or three trial increasing the sample size and comparing it to common treatments or sometimes placebos. Once it has shown safety and efficacy in a phase two or three trial, it can then go for Food and Drug Administration (FDA) approval. There are also phase four and five trials that help with translating the evidence into practice and community settings (Titler, 2018).
In my specialty area of oncology, we are constantly hearing about clinical trials and new therapies coming to market. It is critical to have a good understanding of what each phase of the trial consists of and what the outcomes really mean to the patient.
References
Eske, J. (2020, August 31). In vivo vs. in vitro: What is the difference? Medical News Today. Retrieved June 17, 2021, from https://www.medicalnewstoday.com/articles/in-vivo-vs-in-vitro
Mackey, A., & Bassendowski, S. (2017). The history of evidence-based practice in nursing education and practice. Journal of Professional Nursing, 33(1), 51–55. https://doi.org/10.1016/j.profnurs.2016.05.009
Titler, M. G. (2018). Translation Research in Practice: An Introduction. Online Journal of Issues in Nursing, 23(2). https://doi.org/10.3912/OJIN.Vol23No02Man01
Description:
Learners will select a valid nursing practice problem for an evidence-based practice project proposal. The project will be completed in sections, beginning in NUR-550 and culminating in a final written paper detailing the evidence-based practice proposal in NUR-590.
The purpose of this assignment is to select a relevant nursing practice problem for your evidence-based practice project proposal. To identify a relevant problem, consider problems generally faced in nursing practice (coordination of health care, assessment, education, patient
support, trauma prevention, recovery, health screenings, etc.). Use the “PICOT Draft” template to complete this assignment.
Use a national, state or local population health care database to research indicators of disparity. Choose a mortality/morbidity indicator to identify a clinical problem or issue that you want to explore pertaining to a population of focus. Use this indicator to begin to formulate a PICOT statement.
Refer to the “Evidence-Based Practice Project Proposal – Assignment Overview” document for an overview of the evidence-based practice project proposal assignments.
You are required to cite one peer-reviewed source to complete this assignment. Sources must be published within the last 5 years and appropriate for the assignment criteria and nursing content.
While APA style is not required for the body of this assignment, solid academic writing is expected, and documentation of sources should be presented using APA formatting guidelines, which can be found in the APA Style Guide, located in the Student Success Center.
This assignment uses a rubric. Please review the rubric prior to beginning the assignment to become familiar with the expectations for successful completion.
You are not required to submit this assignment to LopesWrite.
Description
Objectives:
1. Identify the different levels of translational research.
2. Differentiate translational research from evidence-based practice.
3. Discuss the application of translational research to population health management.
4. Evaluate sources of translational research.
5. Select a valid nursing practice problem for an evidence-based practice project proposal
Advanced Practice Nursing: Essential Knowledge for the Profession
Description:
Read Chapters 22 and 23 in Advanced Practice Nursing: Essential Knowledge for the Profession.
Evidence-Based Practice in Nursing and Healthcare
Description:
Read Chapter 1 in Evidence-Based Practice in Nursing and Healthcare.
World Health Organization (WHO)
Description:
Explore the World Health Organization (WHO) website.
Centers for Disease Control and Prevention (CDC)
Description:
Explore the Centers for Disease Control and Prevention (CDC) website.
State and County Departments of Health
Description:
Explore the websites of your state and county departments of health and access mortality and morbidity data. The link to the Arizona Department of Health Services website is provided, but students living in other states should access their county and state departments.
Non-Communicable Diseases (NCD) Burden of Disease
Description:
Read “Non-Communicable Diseases (NCD) Burden of Disease,” by the U.S. Department of Health and Human Services, located on the Centers for Disease Control and Prevention website.
GCU Library: Nursing and Health Sciences Research Guide
Description:
Review the “Nursing and Health Sciences” research guide, located on the GCU Library website.
The Electronic Health Record: A Friend or Foe of Translational Research and Evidence-Based Practice?
Description:
Read “The Electronic Health Record: A Friend or Foe of Translational Research and Evidence-Based Practice?” by Chipps et al., from Worldviews on Evidence-Based Nursing (2019).
Evidence-Based Practice
Description:
Read “Evidence-Based Practice” by Melnyk and Fineout-Overholt, from Encyclopedia of Nursing Research (2017).
Translation Research in Practice: An Introduction
Description:
Read “Translation Research in Practice: An Introduction,” by Titler, from Online Journal of Issues in Nursing (2018).
On Biostatistics and Clinical Trials: PICO, PICOTS, PICOTT Framework for Clinical Questions as a Way to Design Clinical Trials
Description:
Read “PICO, PICOTS, PICOTT Framework for Clinical Questions as a Way to Design Clinical Trials,” by Deng, from
On Biostatistics and Clinical Trials (2020).
NUR 550 Discussion: Levels of Translational Research Grading Rubric Guidelines
| Performance Category | 10 | 9 | 8 | 4 | 0 |
| Scholarliness
Demonstrates achievement of scholarly inquiry for professional and academic decisions. |
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| Performance Category | 10 | 9 | 8 | 4 | 0 |
| Application of Course Knowledge –
Demonstrate the ability to analyze, synthesize, and/or apply principles and concepts learned in the course lesson and outside readings and relate them to real-life professional situations |
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| Performance Category | 5 | 4 | 3 | 2 | 0 |
| Interactive Dialogue
Replies to each graded thread topic posted by the course instructor, by Wednesday, 11:59 p.m. MT, of each week, and posts a minimum of two times in each graded thread, on separate days. (5 points possible per graded thread) |
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Summarizes what was learned from the lesson, readings, and other student posts for the week. |
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| Minus 1 Point | Minus 2 Point | Minus 3 Point | Minus 4 Point | Minus 5 Point | |
| Grammar, Syntax, APA
Note: if there are only a few errors in these criteria, please note this for the student in as an area for improvement. If the student does not make the needed corrections in upcoming weeks, then points should be deducted. Points deducted for improper grammar, syntax and APA style of writing. The source of information is the APA Manual 6th Edition |
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| 0 points lost | -5 points lost | ||||
| Total Participation Requirements
per discussion thread |
The student answers the threaded discussion question or topic on one day and posts a second response on another day. | The student does not meet the minimum requirement of two postings on two different days | |||
| Early Participation Requirement
per discussion thread |
The student must provide a substantive answer to the graded discussion question(s) or topic(s), posted by the course instructor (not a response to a peer), by Wednesday, 11:59 p.m. MT of each week. | The student does not meet the requirement of a substantive response to the stated question or topic by Wednesday at 11:59 pm MT. |