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NUR 550 Discussion: Levels of Translational Research

NUR 550 Discussion Levels of Translational Research

There are three levels of translational research: -T1- Basic research that is used to develop a new treatment or therapy. This research is conducted in a laboratory setting and aims to understand the fundamental biology behind a disease or condition. -T2- Preclinical research that is used to test the safety and efficacy of a new treatment or therapy in animals (Fort et al., 2017). This research is conducted in a laboratory setting and helps to determine if the treatment or therapy is safe and effective for humans. And -T3- Clinical trials that are used to test the safety and efficacy of a new treatment or therapy in humans. This research is conducted with patients who have the disease or condition being studied.

There are several ways in which translational research is different from evidence-based practice (EBP). The first has to do with the idea of “evidence.” In translational research, scientists strive to move discoveries made in the laboratory into practical applications that can be used in the real world. This means that the findings of translational research are based on sound scientific evidence. In contrast, EBP relies on a body of research that has been evaluated and found to be reliable (Parija, 2020). The goal of EBP is to use this existing body of knowledge to make informed decisions about patient care. Another difference between translational research and has to do with the time frame involved. Translational take longer time compared to EBP given the stages that has to be accomplished in the entire process.

Population health management (PHM) is the field of public health that concerns itself with the health and well-being of defined

NUR 550 Discussion Levels of Translational Research

NUR 550 Discussion Levels of Translational Research

populations. It is a relatively new field, having been formally recognized only in the past few decades (Fort et al., 2017). PHM is built upon the foundation of translational research, which is the process of applying knowledge and findings from basic science research to practical applications in human health care. The goal of PHM is to improve population health by using knowledge gleaned from translational research to develop and implement interventions at the individual, community, and societal levels. Some common interventions employed by PHM practitioners include educational programs, screenings, targeted treatments, and policy changes.

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References

Fort, D. G., Herr, T. M., Shaw, P. L., Gutzman, K. E., &Starren, J. B. (2017). Mapping the evolving definitions of translational research. Journal of clinical and translational science1(1), 60-66.https://www.cambridge.org/core/journals/journal-of-clinical-and-translational-science/article/mapping-the-evolving-definitions-of-translational-research/39D2FB59ECC2F0C862E49E03E2403E12

Parija, S. C. (2020). Translational Research in Nursing… Vistas Galore.https://web.archive.org/web/20201212092716id_/https://pjn.sbvjournals.com/doi/pdf/10.5005/jp-journals-10084-12165

Topic 1 DQ 1

Description:

Identify the different levels of translational research. Explain how translational research is different from evidence-based practice and discuss its application to population health management.

 

Description:

Learners will select a valid nursing practice problem for an evidence-based practice project proposal. The project will be completed in sections, beginning in NUR-550 and culminating in a final written paper detailing the evidence-based practice proposal in NUR-590.

The purpose of this assignment is to select a relevant nursing practice problem for your evidence-based practice project proposal. To identify a relevant problem, consider problems generally faced in nursing practice (coordination of health care, assessment, education, patient
support, trauma prevention, recovery, health screenings, etc.). Use the “PICOT Draft” template to complete this assignment.

Use a national, state or local population health care database to research indicators of disparity. Choose a mortality/morbidity indicator to identify a clinical problem or issue that you want to explore pertaining to a population of focus. Use this indicator to begin to formulate a PICOT statement.

Refer to the “Evidence-Based Practice Project Proposal – Assignment Overview” document for an overview of the evidence-based practice project proposal assignments.

You are required to cite one peer-reviewed source to complete this assignment. Sources must be published within the last 5 years and appropriate for the assignment criteria and nursing content.

While APA style is not required for the body of this assignment, solid academic writing is expected, and documentation of sources should be presented using APA formatting guidelines, which can be found in the APA Style Guide, located in the Student Success Center.

Identify the different levels of translational research. Explain how translational research is different from evidence-based practice and discuss application to population health management.

Re: Topic 1 DQ 1

Translational research is form of clinical research that was first seen around 1993 (Rubio et al, 2010). So as far as research goes this is a fairly new was to look into things. There is also no clear definition of translational research, but essentially it encompasses two areas of translation one being the information obtained in pre-clinical studies, lab research and the other being the adaptation of best practices in the community with their cost effectiveness (Rubio et al, 2010). There are three levels of translational research, starting with T1, which involves the beginning research or development of an intervention, including the lab research, observational research and phase I and II clinical trials (Translational Research, n.d.). The second level is T2 the translation to patients, testing these interventions and their efficacy on the patient populace, including phase III clinical trials, studying how these new interventions work with disease processes and creating new guidelines with up-to-date information (Translational Research, n.d.). The third level is T3 disseminating and implementation of all the research into daily practice, creating the research evidence found into evidence-based practices across the profession (Translational Research, n.d.).

From this information there isn’t a difference between evidence-based practice and translational research, it is just a way to get to evidence based practice. By following the ‘three T’s’, the final step is to put all of this research into practice, as evidence-based practice. For public health this means the most up to date care and information as the natural progression of translational practice ends with practice. If there is no research being done in the area however, this has a negative impact on the population, as there is not up to date EPB related to that disease process and/or its co morbidities.

Rubio, D. M., Schoenbaum, E. E., Lee, L. S., Schteingart, D. E., Marantz, P. R., Anderson, K. E., Platt, L. D., Baez, A., & Esposito, K. (2010). Defining translational research: implications for training. Academic medicine : journal of the Association of American Medical Colleges85(3), 470–475. https://doi.org/10.1097/ACM.0b013e3181ccd618

Translational Research – Defining the “T’s” | Translational Cancer Research Network. (n.d.). Www.Tcrn.Unsw.Edu. Retrieved June 18, 2021, from http://www.tcrn.unsw.edu.au/translational-research-definitions

 

RESPOND HERE (150 W0ORDS, 2 REFERENCES)

 

This is insightful Sarah, translational research is form of clinical research that was first seen around 1993. So as far as research goes this is a fairly new was to look into things. Translational research refers to a form of study that seeks to produce more applicable, meaningful and valid outcomes that can directly impact human health. The main objective or purpose of the translational research is to translate essential science discoveries more quickly and efficiently into practices (Eske, 2020). Translational research has been applied frequently by different researchers to enhance research processes geared towards achieving quality treatment processes and effective patient outcomes. There are three major level of translational research including T1, T2, and T3. These levels need to be incorporated into the research processes to ensure accuracy and effective outcomes in the research processes (Woolf, 2018). Level I or T1 often involves development of interventions to ensure that the entire research processes is done effectively in line with the set objectives.

References

Woolf, S. H. (2018). The meaning of translational research and why it matters. Jama299(2), 211-213. https://jamanetwork.com/journals/jama/article-abstract/1149350

Eske, J. (2020, August 31). In vivo vs. in vitro: What is the difference? Medical News Today. Retrieved June 17, 2021, from https://www.medicalnewstoday.com/articles/in-vivo-vs-in-vitro

Re: Topic 1 DQ 1

Translational research is a new concept in my view of the world, it is a fairly new concept, as nurses we hear the term evidence-based practice (EBP) and research. Translational research is often thought of as EPB, Translational research is the research of EBP studies as well as the study and translation of EBP interventions into practice (Melnyk & Fineout-Overholt, 2019) Translational research is as stated it translates how EBP “translates” into practice, evidence-based practice is a guide to practice, translation science is the translation to implement the evidence-based research into practice. (Tilter, 2018). Translation research has different components to implementation of preclinical studies, phase one small clinical trials, phase 2&3 larger clinical trials, outcomes from the clinical trials, them phase 5 population outcomes research- these phases offer a “bench to bedside” continuum (Tilter, 2018).

Gaps between the availability of evidence and the placing evidence into practice has shown to partner with poor outcomes by not enabling caregivers to place the evidence into practice. (Tilter, 2018)Transitional research has shown to be beneficial in-patient outcomes and health care management by translating the evidence into practice which improves patient outcomes by the utilization of the evidence. In my field of Labor and delivery I have seen this similar process in the abundance availability of research and evidence of the increased risk of hypertension in pregnancy. Yet the physicians I practice with implement in very many ways through lack of translation causing early inductions and higher risk to the infants. When implementing a new technology, evidence or practice it is important to understand the research and evidence behind it as well as how best to safely implement into practice. (Sung et al., 2020) Translation research is an exciting and has multiple opportunities to advance patient outcomes, as an upcoming APRN in a magnet hospital, utilizing this process with EBP will strongly improve patient care as well as nursing practice.

 

References

Melnyk, B. M., PhD, RN. APRN-CNP, FAANP, FNAP, FAAN, & Fineout-Overholt, E., PhD, RN, FNAP, FAAN. (2019). Evidence-Based Practice in Nursing& Healthcare A Guide to Best Practice (4th ed.). Wolters Kluwer.

Sung, V. W., MD MPH, Tulikangas, P., MD, Bradley, C. S., MD, MSCE, & Rideway, B., MD. (2020). Assessing and adopting New medical devices for Obstetric and Gynecologic care. ACOG135(4), 160–166. Retrieved May 26, 2021, from

Tilter, M. G. (2018). Translation Research in Practice: An Introduction. Online Journal of Issues in Nursing23(2). Retrieved June 16, 2021, from

 

This assignment uses a rubric. Please review the rubric prior to beginning the assignment to become familiar with the expectations for successful completion.

You are not required to submit this assignment to LopesWrite.

 

Description

 

Objectives:

1. Identify the different levels of translational research.
2. Differentiate translational research from evidence-based practice.
3. Discuss the application of translational research to population health management.
4. Evaluate sources of translational research.
5. Select a valid nursing practice problem for an evidence-based practice project proposal

Advanced Practice Nursing: Essential Knowledge for the Profession

Description:

Read Chapters 22 and 23 in Advanced Practice Nursing: Essential Knowledge for the Profession.

Evidence-Based Practice in Nursing and Healthcare

Description:

Read Chapter 1 in Evidence-Based Practice in Nursing and Healthcare.

World Health Organization (WHO)

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Description:

Explore the World Health Organization (WHO) website.

Centers for Disease Control and Prevention (CDC)

Description:

Explore the Centers for Disease Control and Prevention (CDC) website.

State and County Departments of Health

Description:

Explore the websites of your state and county departments of health and access mortality and morbidity data. The link to the Arizona Department of Health Services website is provided, but students living in other states should access their county and state departments.

Non-Communicable Diseases (NCD) Burden of Disease

Description:

Read “Non-Communicable Diseases (NCD) Burden of Disease,” by the U.S. Department of Health and Human Services, located on the Centers for Disease Control and Prevention website.

GCU Library: Nursing and Health Sciences Research Guide

Description:

Review the “Nursing and Health Sciences” research guide, located on the GCU Library website.

The Electronic Health Record: A Friend or Foe of Translational Research and Evidence-Based Practice?
Description:

Read “The Electronic Health Record: A Friend or Foe of Translational Research and Evidence-Based Practice?” by Chipps et al., from Worldviews on Evidence-Based Nursing (2019).

Evidence-Based Practice

Description:

Read “Evidence-Based Practice” by Melnyk and Fineout-Overholt, from Encyclopedia of Nursing Research (2017).

Translation Research in Practice: An Introduction

Description:

Read “Translation Research in Practice: An Introduction,” by Titler, from Online Journal of Issues in Nursing (2018).

On Biostatistics and Clinical Trials: PICO, PICOTS, PICOTT Framework for Clinical Questions as a Way to Design Clinical Trials
Description:

Read “PICO, PICOTS, PICOTT Framework for Clinical Questions as a Way to Design Clinical Trials,” by Deng, from
On Biostatistics and Clinical Trials (2020).

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