NRS 493 Topic 8 DQ 2 Define clinical significance, and explain the difference between clinical and statistical significance

NRS 493 Topic 8 DQ 2 Define clinical significance, and explain the difference between clinical and statistical significance

NRS 493 Topic 8 DQ 2 Define clinical significance, and explain the difference between clinical and statistical significance

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Topic 8 DQ 2

Jun 6-10, 2022

Not all EBP projects result in statistically significant results. Define clinical significance, and explain the difference between clinical and statistical significance. How can you use clinical significance to support positive outcomes in your project?

Sharia Jones

Posted Date

Jun 12, 2022, 3:00 PM

Replies to Sharia Jones

Statistical significance indicates the reliability of a study’s results, while clinical significance reflects its impact on clinical practice. To expound, measures of statistical significance quantify the probability of a study’s results being due to chance. Statistical significance is a mathematical measure that is used to determine variances between groups based on certain mathematical criteria.  Clinical significance, on the other hand, refers to the magnitude of the actual treatment effect, which will determine whether the results of the trial are likely to impact current medical/clinical practice (Ranganathan, Pramesh & Buyse, 2015). For example, a study may have true findings and a truly effective outcomes (statistically significant), however, the effect may be very small compared to the financial cost, or resources it may utilize to implement, deeming the study non-clinically significant. The measure of clinical significance is the determining factor whether an evidence-based practice will be implemented in the healthcare system (Schober, Bossers & Schwarte, 2018). Based on the positive outcomes of my change project, if true clinical significance is proven there is a greater potential for continued implementation into standard practice at the facility.

 

References

 

Ranganathan, P., Pramesh, C. S., & Buyse, M. (2015). Common pitfalls in statistical analysis: Clinical versus statistical significance. Perspectives in clinical research6(3), 169–170. https://doi.org/10.4103/2229-3485.159943

Schober, Patrick MD, PhD, MMedStat; Bossers, Sebastiaan M. MD, MSc; Schwarte, Lothar A. MD, PhD, MBA Statistical Significance Versus Clinical Importance of Observed Effect Sizes: What Do P Values and Confidence Intervals Really Represent?, Anesthesia & Analgesia: March 2018 – Volume 126 – Issue 3 – p 1068-1072 http://doi:10.1213/ANE.0000000000002798

Esther Obiyaa

replied toSharia Jones

Jun 12, 2022, 7:08 PM

  • Replies to Sharia Jones

Hello Sharia,

Thank you for your educational post. In addition to what you elaborated on, It is always essential to determine the statistical significance of research before significance because clinical research study results, which are statistically significant, are often interpreted as clinically important. We can use clinical significance to support the positive outcomes of our project outcome by ensuring that the result is statistically significant (Heavey, 2015)

Reference

 

Heavey, E. (2015). Differentiating statistical significance and clinical significance. American Nurse Today, 10(5): 26-28. Available from https://www.brockport.edu/daily_eagle/doc/2015-04/item_8038_7659.pdf

 

 

  • Ayda Nahorai

replied toSharia Jones

Jun 12, 2022, 7:36 PM

  • Replies to Sharia Jones

Statistical significance has been used extensively to evaluate the results of research studies. Nevertheless, it offers only limited information to clinicians. Assessing clinical relevance can facilitate interpreting the research results into clinical practice. Statistical significance is a measurement of how likely it is that the difference between two groups, models, or statistics occurred by chance or occurred because two variables are related to each other. This means that a “statistically significant” finding is one in which it is likely the finding is accurate, reliable, and not due to chance.

  • Lydia Kwofie

replied toSharia Jones

Jun 12, 2022, 7:37 PM

Replies to Sharia Jones

Hi Sharia,

In the case of evidence-based research practice, it is essential to determine statistical significance of the research results before ascertaining whether the results are clinically significant. The main reason for establishing statistical significance before determining clinical significance is that clinical significance is determined after evaluating several research or experimental findings and confirming that they are statistically significant (Polit, 2017). I can make use of clinical significance to inform positive outcomes in my project outcome by ensuring that the results are statistically significant because clinical significance is informed by statistically significant results.

 

Polit, D. F. (2017). Clinical significance in nursing research: A discussion and descriptive analysis. International Journal of Nursing Studies73, 17-23.

 

  • Sharia Jones

replied toLydia Kwofie

Jun 12, 2022, 11:56 PM

    • Replies to Lydia Kwofie

Hi Lydia,

Statistical significance is a mathematical measure that is used to determine variances between groups based on certain mathematical criteria.  Clinical significance, on the other hand, refers to the magnitude of the actual treatment effect, which will determine whether the results of the trial are likely to impact current medical/clinical practice. Clinical significance indicates whether the results of a

NRS 493 Topic 8 DQ 2 Define clinical significance, and explain the difference between clinical and statistical significance
NRS 493 Topic 8 DQ 2 Define clinical significance, and explain the difference between clinical and statistical significance

study are meaningful or not for several stakeholders. A clinically relevant intervention is the one whose effects are large enough to make the associated costs, inconveniences, and harms worthwhile (Armijo-Olivo, 2018).

 

References

 

Armijo-Olivo S. (2018). The importance of determining the clinical significance of research results in physical therapy clinical research. Brazilian journal of physical therapy22(3), 175–176. https://doi.org/10.1016/j.bjpt.2018.02.001

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Grading Rubric Guidelines

Performance Category 10 9 8 4 0
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Performance Category  5 4 3 2 0
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Replies to each graded thread topic posted by the course instructor, by Wednesday, 11:59 p.m. MT, of each week, and posts a minimum of two times in each graded thread, on separate days.

(5 points possible per graded thread)

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Summarizes what was learned from the lesson, readings, and other student posts for the week.

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The source of information is the APA Manual 6th Edition

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  • 6-7 errors in APA format.
  • Writing responses have 6-7 grammatical, spelling and punctuation errors.
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  • 8-10 errors in APA format.
  • Writing responses have 8-10 grammatical, spelling and punctuation errors.
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  • Post contains greater than 10 errors in APA format.
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The student must provide a substantive answer to the graded discussion question(s) or topic(s), posted by the course instructor (not a response to a peer), by Wednesday, 11:59 p.m. MT of each week. The student does not meet the requirement of a substantive response to the stated question or topic by Wednesday at 11:59 pm MT.

Check Out Also: NRS 493 Topic 8 DQ 1 Based on how you will evaluate your EBP project, which independent and dependent variables do you need to collect?