DNP 801 Topic 5 DQ 2 Explain the difference between statistical significance and clinical significance

DNP 801 Topic 5 DQ 2 Explain the difference between statistical significance and clinical significance

DNP 801 Topic 5 DQ 2 Explain the difference between statistical significance and clinical significance

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Explain the difference between statistical significance and clinical significance. Provide an example for each. How do statistical significance and clinical significance apply to a quality improvement initiative, like your future DPI Project?

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AS

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Mar 24, 2022, 10:05 PM

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Explain the difference between statistical and clinical significance. Provide an example for each. How do statistical significance and clinical significance apply to quality improvement initiative, like your future DPI project?

Evidence-based practices and research in the medical field have provided enormous information that can be applied in clinical practice. However, it is important to understand the differences between statistical and clinical significance since they are important aspects in the clinical field, application of evidence-based research, as well as clinical projects. Therefore, Sharma, (2021) explains that the main difference between clinical and statistical significance is that clinical significance observes dissimilarity between two groups or two treatment modalities while statistical significance on the other hand shows whether there is any mathematical significance to the carried analysis of the results or not.

Additionally, Alsoufi, (2018) adds that statistically significant results do not necessarily mean that the results are clinically relevant because many outcomes can be statistically significant but not clinically relevant. An example of clinical significance can be explained using two different chemotherapy agents for cancer whereby drug A is less expensive as compared to the usual chemotherapy agents and it increases the survival of treated patients by five years while drug B is more expensive than the usual chemotherapy drugs and increases the survival of the treated patient five months. Drug A is considered to be clinically significant because it increases the patients’ survival by five years and it is inexpensive while the statistical significance is the difference in values recorded in analysis when differentiating the years and months of patient survival.

Statistical and clinical significance is very important and can be applied in clinical practice to improve service quality. Clinically significant research outcomes are considered to be clinically viable and can be implemented in healthcare facilities to improve the quality of healthcare services thus improving patient outcomes (Polit, 2017). From the example provided earlier in comparing the effectiveness of drugs A and B, drug A can be used in healthcare facilities in the treatment cancer patients undergoing chemotherapy thus improving their survival by five years.

References DNP 801 Topic 5 DQ 2 Explain the difference between statistical significance and clinical significance

Alsoufi, B. (2018). Statistical versus clinical significance. The Journal of Thoracic and Cardiovascular Surgery, 155(1), 344-345.DOI:https://doi.org/10.1016/j.jtcvs.2017.08.108

Polit, D. F. (2017). Clinical significance in nursing research: A discussion and descriptive analysis. International Journal of Nursing Studies, 73, 17-23. https://doi.org/10.1016/j.ijnurstu.2017.05.002

Sharma H. (2021). Statistical significance or clinical significance? A researcher’s dilemma for appropriate interpretation of research results. Saudi journal of anaesthesia, 15(4), 431–434. https://doi.org/10.4103/sja.sja_158_21

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Mar 21, 2022, 8:28 PM

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Clinical significance is the importance of the research findings. How will it affect the clinical care being provided or how will it affect the clinical decision that needs to be made for care? While statistical significance is the knowledge that the results were based on facts and the interventions performed and not by chance or an accident that happened (Melnyk, & Fineout-Overholt, 2018).  The extent to which random errors in a study will affect it, is reported by using the statistical significance which is represented by p values (Melnyk, & Fineout-Overholt, 2018). When the clinical and statistical significance of a study is not understood, it can lead to misleading reports of the study results and the effects of the study. For instance, with clinical significance, if a study does not randomly assign participants to a particular group, there is a possibility that a lot of sick people could be on one group by chance and that will affect the results of the study (Melnyk, & Fineout-Overholt, 2018).

On the other hand, the statistical significance which is used to determine fact or chance, accepts or rejects the hypothesis, that is, what the author believes will happen. For instance, when an author compares two groups stating that the administration of pain medication to the intervention group and a placebo to the control group, stating that the medication will make a difference. The null hypothesis will be that it will not make a difference. Hence, the p value is used to determine the statistical significance. When the p value is small with large samples, it can lead to the study being reported as statistically significant but clinically insignificant while large p values with small sample sizes can be clinically significant and reported as statistically insignificant (Melnyk, & Fineout-Overholt, 2018).

When a study is clinically significant, it helps to improve the medical, physical, emotional and social aspects of care for a patient. It includes both the objective effects such as function, the duration of the illness and how long life is prolonged and the subjective effects refers to the improvement in their attitude, mood, and wellbeing, decrease in pain and increased comfort. Even though statistical

significance does not mean clinical significance but it leads to the improvement in the care of the patient, therefore, in a DPI project, researchers and clinicians should not discount either but should pay attention to both to improve the outcome for the patient to decrease the chances of reporting a biased study (Sharma, 2021).

References: DNP 801 Topic 5 DQ 2 Explain the difference between statistical significance and clinical significance

Melnyk, B. M., & Fineout-Overholt, E. (2018). Evidence-based practice in nursing & healthcare: A guide to best practice. LWW.

Sharma, H. (2021). Statistical significance or clinical significance? A researcher’s dilemma for appropriate interpretation of research results. Saudi Journal of Anaesthesia, 15(4), 431.

https://doi.org/10.4103/sja.sja_158_21

 

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DNP 801 Topic 5 DQ 2 Explain the difference between statistical significance and clinical significance Grading Rubric Guidelines

Performance Category	10	9	8	4	0
Scholarliness Demonstrates achievement of scholarly inquiry for professional and academic decisions.	Provides relevant evidence of scholarly inquiry clearly stating how the evidence informed or changed professional or academic decisions Evaluates literature resources to develop a comprehensive analysis or synthesis. Uses valid, relevant, and reliable outside sources to contribute to the threaded discussion	Provides relevant evidence of scholarly inquiry but does not clearly state how the evidence informed or changed professional or academic decisions. Evaluates information from source(s) to develop a coherent analysis or synthesis. Uses some valid, relevant, reliable outside sources to contribute to the threaded discussion.	Discusses using scholarly inquiry but does not state how scholarly inquiry informed or changed professional or academic decisions. Information is taken from source(s) with some interpretation/evaluation, but not enough to develop a coherent analysis or synthesis. Little valid, relevant, or reliable outside sources are used to contribute to the threaded discussion. Demonstrates little or no understanding of the topic.	Discusses using scholarly inquiry but does not state how scholarly inquiry informed or changed professional or academic decisions. Information is taken from source(s) without any interpretation/evaluation. The posting uses information that is not valid, relevant, or reliable	No evidence of the use of scholarly inquiry to inform or change professional or academic decisions. Information is not valid, relevant, or reliable
Performance Category	10	9	8	4	0
Application of Course Knowledge – Demonstrate the ability to analyze, synthesize, and/or apply principles and concepts learned in the course lesson and outside readings and relate them to real-life professional situations	Posts make direct reference to concepts discussed in the lesson or drawn from relevant outside sources; Applies concepts to personal experience in the professional setting and or relevant application to real life.	Posts make direct reference to concepts discussed in the lesson or drawn from relevant outside sources. Applies concepts to personal experience in their professional setting and or relevant application to real life Interactions with classmates are relevant to the discussion topic but do not make direct reference to lesson content	Posts are generally on topic but do not build knowledge by incorporating concepts and principles from the lesson. Does not attempt to apply lesson concepts to personal experience in their professional setting and or relevant application to real life Does not demonstrate a solid understanding of the principles and concepts presented in the lesson	Posts do not adequately address the question posed either by the discussion prompt or the instructor’s launch post. Posts are superficial and do not reflect an understanding of the lesson content Does not attempt to apply lesson concepts to personal experience in their professional setting and or relevant application to real life	Posts are not related to the topics provided by the discussion prompt or by the instructor; attempts by the instructor to redirect the student are ignored No discussion of lesson concepts to personal experience in the professional setting and or relevant application to real life
Performance Category	5	4	3	2	0
Interactive Dialogue Replies to each graded thread topic posted by the course instructor, by Wednesday, 11:59 p.m. MT, of each week, and posts a minimum of two times in each graded thread, on separate days. (5 points possible per graded thread)	Exceeds minimum post requirements Replies to each graded thread topic posted by the course instructor, by Wednesday, 11:59 p.m. MT, of each week, and posts three or more times in each graded thread, over three separate days. Replies to a post posed by faculty and to a peer Summarizes what was learned from the lesson, readings, and other student posts for the week.	Replies to each graded thread topic posted by the course instructor, by Wednesday, 11:59 p.m. MT, of each week, and posts a minimum of two times in each graded thread, on separate days Replies to a question posed by a peer Summarizes what was learned from the lesson, readings, and other student posts for the week.	Meets expectations of 2 posts on 2 different days. The main post is not made by the Wednesday deadline Does not reply to a question posed by a peer or faculty	Has only one post for the week Discussion posts contain few, if any, new ideas or applications; often are a rehashing or summary of other students’ comments	Does not post to the thread No connections are made to the topic
	Minus 1 Point	Minus 2 Point	Minus 3 Point	Minus 4 Point	Minus 5 Point
Grammar, Syntax, APA Note: if there are only a few errors in these criteria, please note this for the student in as an area for improvement. If the student does not make the needed corrections in upcoming weeks, then points should be deducted. Points deducted for improper grammar, syntax and APA style of writing. The source of information is the APA Manual 6th Edition	2-3 errors in APA format. Written responses have 2-3 grammatical, spelling, and punctuation errors. Writing style is generally clear, focused, and facilitates communication.	4-5 errors in APA format. Writing responses have 4-5 grammatical, spelling and punctuation errors. Writing style is somewhat focused.	6-7 errors in APA format. Writing responses have 6-7 grammatical, spelling and punctuation errors. Writing style is slightly focused making discussion difficult to understand.	8-10 errors in APA format. Writing responses have 8-10 grammatical, spelling and punctuation errors. Writing style is not focused, making discussion difficult to understand.	Post contains greater than 10 errors in APA format. Written responses have more than 10 grammatical, spelling and punctuation errors. Writing style does not facilitate communication. The student continues to make repeated mistakes in any of the above areas after written correction by the instructor
	0 points lost				-5 points lost
Total Participation Requirements per discussion thread	The student answers the threaded discussion question or topic on one day and posts a second response on another day.				The student does not meet the minimum requirement of two postings on two different days
Early Participation Requirement per discussion thread	The student must provide a substantive answer to the graded discussion question(s) or topic(s), posted by the course instructor (not a response to a peer), by Wednesday, 11:59 p.m. MT of each week.				The student does not meet the requirement of a substantive response to the stated question or topic by Wednesday at 11:59 pm MT.

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